The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

San Francisco 49ers linebacker Fred Warner recently revealed that he has been playing through a bone fracture in his ankle, ...

On Tuesday morning's PFT Live, I threw out the idea of the Bears ditching the normal approach to hiring head coaches and calling the 49ers to see whether they'd be willing to trade Kyle Shanahan.

San Francisco 49ers DB Deommodore Lenoir is showcasing his support for athletes with Down syndrome through custom-designed ...

Next, Nick debates if the 49ers championship window is closed, and what the Falcons should do with their QB situation. Later, Detective Wright returns to solve some of the NFL’s largest mysteries.

Join Packers Head Coach Matt LaFleur and analyst Larry McCarren as they recap the Packers' Week 13 win over Miami and preview ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Christian McCaffrey practiced little and played less this season, seeing action in four games with 65 touches. He is out for the season with his knee injury that will require a six-week recovery.